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48 capsules of organic Kutki (Picrorhiza kurroa) in vegetable capsules
This may be the most powerful liver cleanse you can do. One capsule a day is the typical dose. Ingesting 2 to3 capsules a day is said by Ayurvedic sources to diminish the amount of estrogen in the body. This doseage should not be taken unless there is an issue with too much estrogen, as in the case of estrogen dominant breast cancer. It should not be taken with drugs or if one is experiencing diarrhea or hypoglycemia.
“Picrorhiza kurroa is a herb from Ayurveda that is commonly called Kutki or Kutaki. It has been a rare and endangered plant for decades. This Kutki is sustainably grown. It contains a 'bitter principle' which is a mixture of two molecules, the irioid glycosides known as picroside I and picroside II (picroside II also being called kutkoside) and the mixture overall is then called kutkin or picroliv. Overall, these are the active components.
The herb itself, due solely to the kutkin molecules, appears to be potently hepatoprotective (protective of the liver) when ingested prior to or taken after exposure to a toxin. The protective effects seem to extend to all tested toxins or stressors that are known to alter liver function, and appear to also extend to states of intrinsic liver dysfunction (viral hepatitis and NAFLD from a high fat diet). Most notably it is protective against Tylenol, alcohol and the deathcap mushroom with a potency that is greater than silymarins (the active parts of milk thistle supplementation).” https://examine.com/supplements/picrorhiza-kurroa/
"Intervention with standardized plant extracts of P. kurroa regressed several features of NAFLD like lipid content of the liver tissue, morphological regression of fatty infiltration, hypolipidemic activity, and reduction of cholestatis. " https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087357/
Picrorhiza kurroa Royle ex Benth is a perennial herb and is traditionally well known in Indian ayurvedic system for the treatment of liver and respiratory disorders. It is also used in chronic fevers, treatment of dyspepsia, diarrhoea and scorpion sting . P. kurroa has pharmacological application as an antioxidant, anti-inflammatory, anti-allergic, hepatoprotective, choleretic, anti-asthmatic and anti-cancerous activity due to active iridoid glycosides present in the plant . Of the total 22 iridoid glycosides present in the genus Picrorhiza, P. kurroa posseses 7 distinct iridoid glycosides namely kutkin, kutkoside, picroside V, pikuroside, mussaenosidic acid, bartsioside and boschnaloside . The iridoid glycosides of P. kurroa are monoterpenes biosynthesized from isoprene and typically occur as glycosides. Plants use these glycosides for their protection and defense against infection from different microorganisms and insects. These iridoid glycosides are effective in treating hepatic, inflammatory, bacterial, viral, mutagenic, cancer and other infections" https://www.sciencedirect.com/science/article/pii/S0753332218351965?fbclid=IwAR0o-ksFzIACk93SOO-jS_-LjiOlgSeGdqEU75FKSoD9My3SKoqtn3GgOxA
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