Kalmegh capsules or powder
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Ayurveda recommends taking these twice a day for virus or tumors. If you want to use this plant medicine for tumors, please keep in mind that it is only one part of this sophisticated multi-therapy system. We recommend you contact a Vaidya in your area or make an appointment with Athena on the Healing page of this site to understand the therapies used for each specific type of cancer. Do not take during pregnancy.
Organic Kalmegh, andrographis paniculata,
96 vegetarian capsules $42
Three ounces of powdered herb $38
This plant medicine has been used for thousands of years in the healing system of Ayurveda. Here are some medical studies that confirm its use:
"The results indicated that Andro could significantly inhibit the proliferation of human breast cancers, and suppress COX-2 expression at both protein and mRNA levels. Furthermore, Andro could dose-dependently inhibit COX-2-mediated angiogenesis in human endothelial cells. We have also found that Andro significantly promoted the activation of cytochrome c and activated caspase-dependent apoptotic signaling pathway. Our further explorations demonstrated that Andro inhibited the binding of the transactivators CREB2, C-Fos and NF-κB and blocked the recruitment of coactivator p300 to COX-2 promoter. Moreover, Andro could effectively inhibit the activity of p300 histone acetyltransferase (HAT), thereby attenuating the p300-mediated acetylation of NF-κB. Besides, Andro could also dramatically inhibit the migration, invasion and tubulogenesis of HUVECs in vitro. In addition, Andro also exhibited effective anti-tumor efficacy as well as angiogenesis inhibition in vivo." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186120/
"In conclusion A. paniculata extracts significantly reduced the number of aberrant cells and frequencies of aberration per cell at each concentration and duration of exposure in vivo; similarly it reduced chromosomal aberrations and sister chromatid exchanges and replication index was enhanced in vitro that was statistically significant at <0.05 level." https://www.sciencedirect.com/science/article/pii/S1110863013000992
Another in vivo study. This one on colon cancer.
"The findings from this study suggested that A. paniculata possesses antioxidant, anti-proliferative and antimetastatic activities and hence, has the potential to offer new anti-cancer therapeutic agent. The bioactivity and bioavailability of A. paniculata against cancer was suggested to be due to its diterpenoid and flavonoid contents. Previous studies have discussed the relationship between diterpenoids and cancer prevention [54]. Furthermore, diterpenoids have been tested on HT29, the colon cancer cell line, and have potent effect on the inhibition of HT-29 proliferation [55]–[56]. Flavonoid and diterpenes isolated from A. paniculata have been reported for their antioxidant properties and their ability to protect cells from lipid peroxidation [43]. Taken together, our results highlight the chemoprotective attribution of A. paniculata on the colon mucosal and submucosal layers and propose some possible components of the early/mid stages of carcinogenic cells proliferation and filtration that could be interrupted efficiently after two weeks of administration, guaranteeing the preservation of the colon integrity and functionality." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229078/
Here is some information about dosage from research done at a hospital in Tennessee. http://thechildrenshospitalnashville.com/hl/?/21485/Andrographis Clinical trials in children with upper respiratory tract infection reported the use of andrographolide 30 mg daily for 10 days according to http://www.drugs.com/npp/kalmegh.html
This is a pretty comprehensive compendium of the many uses of Kalmegh from the point of view of western medicine. https://examine.com/supplements/andrographis-paniculata/
Kalmegh contains a rare plant chemical called andrographolide, which has been found to significantly boost the concentration of certain cancer-fighting cells called cytotoxic T lymphocytes. These lymphocytes circulate in your blood stream and attack any cancerous cells that they encounter. Because it has the ability to stimulate their activity, this means that your body becomes better protected against the disease.
In addition, kalmegh increases the amount of other immune-protective chemicals, such as interleukin-2 and gamma-interferon, which help shield your organs against infection and cancer (Immunopharmacol Immunotoxicol. 2007;29(1):81-93).
In fact, it has been found to be so effective against cancer that drug companies have honed in on its profit potential and created synthetic versions of the plant for the purpose of developing cancer-fighting drugs.
Research on Kalmegh In a research report published by the Faculty of Medicine and Health Sciences, Universiti Putra in Malaysia, scientists concluded that: Compounds from this herb were found to be selective towards leukaemia, colon cancer cells, ovarian and renal cancer cells. Analysis indicated that the anti-cancer activities of these new class of compounds were not similar to that of standard anti-cancer agents, suggesting novel mechanisms of action (J. Phytochemistry. 2007 Mar;68(6):904-12).
“The results of our study suggest that Kalmegh extract protects alcohol-induced toxic-effect in liver tissue.” http://www.ncbi.nlm.nih.gov/pubmed/667249
“In the present study, kalmegh (0.01 microg/7ml culture media) was used along with the highest dose of arsenic; the results showed that arsenic induced increase in these genotoxic endpoints were fairly diminished by kalmegh. In addition, mutagenic in vitro effect of ethyl methanesulphonate (EMS) was used as a positive control in this study. It is thus concluded from this study that kalmegh has a protective role in arsenic toxicity.” http://www.ncbi.nlm.nih.gov/pubmed/17482447
The study indicates that the regenerative capability elicited by kalmegh is possibly due to its ability to reactivate liver function enzymes that catalyze the reaction of several biochemical and synthetic processes and that it may be useful for severe liver damage conditions. http://www.ncbi.nlm.nih.gov/pubmed/19679627
“Oral administration of a single dose of kalmegh leaf extract to adult male albino rats produced a dose-related and time-dependent characteristic activation of brush-border membrane-bound hydrolases, viz. lactase, maltase and sucrase in three regions of small intestine… Maximum stimulation of lactase and maltase was noted after 30 consecutive days of treatment while sucrase exhibited maximum activation after 15 consecutive of treatment with either KE or A. These results suggest that both KE and A accelerate intestinal digestion and absorption of carbohydrate by activating these intestinal disaccharidases. http://www.ncbi.nlm.nih.gov/pubmed/3938507
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