Malarial diseases, 96 capsules
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Contains organic: Artemisia, black pepper, guduchi, haritaki, coriander, ginger, holy basil.
Artemesia has been used in Africa to heal from malaria very successfully with less side effects than the drugs. This study explains why:
"Artemisinin from the plant Artemisia annua (A. annua) L, and used as artemisinin combination therapy (ACT), is the current best therapeutic for treating malaria, a disease that hits children and adults especially in developing countries. Traditionally, A. annua was used by the Chinese as a tea to treat “fever”. More recently, investigators have shown that tea infusions and oral consumption of the dried leaves of the plant have prophylactic and therapeutic efficacy. The presence of a complex matrix of chemicals within the leaves seems to enhance both the bioavailability and efficacy of artemisinin. Although about 1000-fold less potent than artemisinin in their antiplasmodial activity, these plant chemicals are mainly small molecules that include other artemisinic compounds, terpenes (mainly mono and sesqui), flavonoids, and polyphenolic acids. In addition, polysaccharide constituents of A. annua may enhance bioavailability of artemisinin."
This study shows that it is good to combine artemesia with other herbs. "we compared the efficacy of oral delivery of the dried leaves of whole plant (WP) A. annua to a comparable dose of pure artemisinin in a rodent malaria model (Plasmodium chabaudi). We found that a single dose of WP (containing 24 mg/kg artemisinin) reduces parasitemia more effectively than a comparable dose of purified drug. This increased efficacy may result from a documented 40-fold increase in the bioavailability of artemisinin in the blood... " https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052746
"derived from the Chinese herb artemisinin, wipes out malaria in more than 96 percent of patients in regions where malaria has become resistant to older drugs, according to drug-maker Novartis. Traditional meds such as chloroquine work in only 50 percent of patients where the parasite is drug-resistant" https://www.scientificamerican.com/article/artemisinin-coartem-malaria-novartis/
Guduchi "Published literature on recent developments in research in Tinospora cordifolia, including original articles and papers in Pubmed and Pubmed Central Databases were taken into study for the report. Information extracted from a total of 175 published articles of which five review articles and cross references thereof were collected. The search criteria were restricted to the roles of the plant in the field of medical advancements and the effects that has been observed with different experiments.
Inclusion criteria
All the reports of experiments on different model types (in vitro, ex vivo, and in vivo) were taken varying from animal and human model systems. Reported data was analysed and represented in the form of figures and tables for the current review. ChemDraw Ultra 9.0 Software, Cambridge soft Life Science Enterprise Solutions was used for drawing the figures in the review. The figures of the compounds were obtained as reported in different journal sources. Tinospora cordifolia extracts are extensively used in various herbal preparations for the treatment of different ailments for its anti-periodic, anti-spasmodic, anti-microbial, anti-osteoporotic, anti-inflammatory, anti-arthritic, anti-allergic, and anti-diabetic properties"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644751/
Haritaki is used to dissolve the lipids surrounding virus.
"Haritaki afforded four immunodeficiency virus type 1 (HIV-1) integrase inhibitors, GA (I) and three galloyl glucoses (II-IV). Their galloyl moiety plays a major role for inhibition against the 3′-processing of HIV-1 integrase of the compounds[63]. T. chebula has also retroviral reverse transcriptase inhibitory activity[64]. It protects epithelial cells against influenza A virus, supporting its traditional use for aiding in recovery from acute respiratory infections[65]. The methanol and aqueous extracts of T. chebula showed a significant inhibitory activity with IC50≤5 µg/mL on human immunodeficiency virus-1 reverse transcriptase[66]. It also demonstrated the therapeutic activity against herpes simplex virus both in vitro and in vitvo tests[67]. These finding prompted a team of Japanese researchers to investigate T. chebulas's effect on human cytomagalovirus (CMV). They found that T. chebula was effective in inhibiting the replication of human cytomagalovirus in vitro and in an AIDS model with immunosuppressed mice and concluded that it may be beneficial for the prevention of CMV diseases and immonocompronised patients[68]. It is also helpful in sexually transmitted diseases and AIDS[69]. Tannins from T. chebula are effective against potato virus x[70].
6.11. Antiprotozoal activity
A combination of T. chebula and four other botanicals (Boerhavia diffusa, Berberis aristata, Tinospora cordifolia, and Zingiber officinale) had a maximum cure rate of 73% in experimental amoebic liver abscess in hamsters[71] and 89% in experimental caecal amoebiasis in rats showing its antiamoebic activity against Entamoeba histolytica[72]. The acetone extract of T. chebula seeds showed anti plasmodial activity against Plasmodium falciparum[73]." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631759/
Holy Basil This herb helps clear the lungs. "studies have found that extracts of holy basil (Ocimim sanctum) inhibit constriction of the bronchial airway passages. Two preliminary clinical trials treated asthma patients with 500 mg of holy basil three times daily for one month. Breathing function improved and the frequency of attacks was reduced." (this was a western experiment. It is not how Ayurvedic physician treat asthma).
Contains organic: Artemisia, black pepper, guduchi, haritaki, coriander, ginger, holy basil.
Artemesia has been used in Africa to heal from malaria very successfully with less side effects than the drugs. This study explains why:
"Artemisinin from the plant Artemisia annua (A. annua) L, and used as artemisinin combination therapy (ACT), is the current best therapeutic for treating malaria, a disease that hits children and adults especially in developing countries. Traditionally, A. annua was used by the Chinese as a tea to treat “fever”. More recently, investigators have shown that tea infusions and oral consumption of the dried leaves of the plant have prophylactic and therapeutic efficacy. The presence of a complex matrix of chemicals within the leaves seems to enhance both the bioavailability and efficacy of artemisinin. Although about 1000-fold less potent than artemisinin in their antiplasmodial activity, these plant chemicals are mainly small molecules that include other artemisinic compounds, terpenes (mainly mono and sesqui), flavonoids, and polyphenolic acids. In addition, polysaccharide constituents of A. annua may enhance bioavailability of artemisinin."
This study shows that it is good to combine artemesia with other herbs. "we compared the efficacy of oral delivery of the dried leaves of whole plant (WP) A. annua to a comparable dose of pure artemisinin in a rodent malaria model (Plasmodium chabaudi). We found that a single dose of WP (containing 24 mg/kg artemisinin) reduces parasitemia more effectively than a comparable dose of purified drug. This increased efficacy may result from a documented 40-fold increase in the bioavailability of artemisinin in the blood... " https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052746
"derived from the Chinese herb artemisinin, wipes out malaria in more than 96 percent of patients in regions where malaria has become resistant to older drugs, according to drug-maker Novartis. Traditional meds such as chloroquine work in only 50 percent of patients where the parasite is drug-resistant" https://www.scientificamerican.com/article/artemisinin-coartem-malaria-novartis/
Guduchi "Published literature on recent developments in research in Tinospora cordifolia, including original articles and papers in Pubmed and Pubmed Central Databases were taken into study for the report. Information extracted from a total of 175 published articles of which five review articles and cross references thereof were collected. The search criteria were restricted to the roles of the plant in the field of medical advancements and the effects that has been observed with different experiments.
Inclusion criteria
All the reports of experiments on different model types (in vitro, ex vivo, and in vivo) were taken varying from animal and human model systems. Reported data was analysed and represented in the form of figures and tables for the current review. ChemDraw Ultra 9.0 Software, Cambridge soft Life Science Enterprise Solutions was used for drawing the figures in the review. The figures of the compounds were obtained as reported in different journal sources. Tinospora cordifolia extracts are extensively used in various herbal preparations for the treatment of different ailments for its anti-periodic, anti-spasmodic, anti-microbial, anti-osteoporotic, anti-inflammatory, anti-arthritic, anti-allergic, and anti-diabetic properties"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644751/
Haritaki is used to dissolve the lipids surrounding virus.
"Haritaki afforded four immunodeficiency virus type 1 (HIV-1) integrase inhibitors, GA (I) and three galloyl glucoses (II-IV). Their galloyl moiety plays a major role for inhibition against the 3′-processing of HIV-1 integrase of the compounds[63]. T. chebula has also retroviral reverse transcriptase inhibitory activity[64]. It protects epithelial cells against influenza A virus, supporting its traditional use for aiding in recovery from acute respiratory infections[65]. The methanol and aqueous extracts of T. chebula showed a significant inhibitory activity with IC50≤5 µg/mL on human immunodeficiency virus-1 reverse transcriptase[66]. It also demonstrated the therapeutic activity against herpes simplex virus both in vitro and in vitvo tests[67]. These finding prompted a team of Japanese researchers to investigate T. chebulas's effect on human cytomagalovirus (CMV). They found that T. chebula was effective in inhibiting the replication of human cytomagalovirus in vitro and in an AIDS model with immunosuppressed mice and concluded that it may be beneficial for the prevention of CMV diseases and immonocompronised patients[68]. It is also helpful in sexually transmitted diseases and AIDS[69]. Tannins from T. chebula are effective against potato virus x[70].
6.11. Antiprotozoal activity
A combination of T. chebula and four other botanicals (Boerhavia diffusa, Berberis aristata, Tinospora cordifolia, and Zingiber officinale) had a maximum cure rate of 73% in experimental amoebic liver abscess in hamsters[71] and 89% in experimental caecal amoebiasis in rats showing its antiamoebic activity against Entamoeba histolytica[72]. The acetone extract of T. chebula seeds showed anti plasmodial activity against Plasmodium falciparum[73]." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631759/
Holy Basil This herb helps clear the lungs. "studies have found that extracts of holy basil (Ocimim sanctum) inhibit constriction of the bronchial airway passages. Two preliminary clinical trials treated asthma patients with 500 mg of holy basil three times daily for one month. Breathing function improved and the frequency of attacks was reduced." (this was a western experiment. It is not how Ayurvedic physician treat asthma).
