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- Alzheimer's one bottle
Alzheimer's one bottle
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This package includes 96 vegetarian capsules of Ashwagandha, Shankhpushpi, Jatamansi root (also known as spikenard), Guggulu; and,
It should be taken with Golden Milk everyday. Buy just the bottle if you already have the ingredients for Golden Milk. You can find the recipe for it on the "Recipe" page of this website.
This also includes Ayurvedic recommendation for diet, lifestyle and a meditation to heal from Alzheimer's.
Ashwagandha is used extensively in Ayurveda as a nervine tonic, and helps the body adapt to stress. A recent double-blind, randomized, placebo-controlled study of the effects of Ashwagandha on stress found that it reduced symptoms of stress and inability to concentrate and reversed forgetfulness.
Turmeric is anti-inflammatory, antiseptic, and antibacterial and has long been used in the Ayurvedic system of medicine. It helps detoxify the liver, balance cholesterol levels, fight allergies, stimulate digestion, creates more synovial fluid in the joints, and boosts immunity. Turmeric tends to bind iron and copper rather than zinc, which may contribute to its protective effect in Alzheimer's disease. You can find the original Ayurvedic recipe for the best use of turmeric,
Golden Milk, on the Recipe page of curanderahealing.com and make your own Golden Milk.
Shankhpushpi is used in various formulas as a nervine tonic for improvement of memory and cognitive function. Primarily, shankhapushpi is used as a brain tonic. It is one of the best and prominent natural medicines that help in improving memory. The whole plant of shankhapushpi is used in medical treatment.
In the Ayurvedic system of medicine, gotu kola is one of the important rejuvenating herbs for nerve and brain cells and is believed to be capable of increasing intelligence, longevity, and memory. Studies have shown that the constituents, asiatic acid and asiaticoside, reduce hydrogen peroxide-induced cell death, decrease free radical concentrations, and inhibit beta-amyloid cell death.
Jatamansi root has a rich history of medicinal use in the Ayurvedic system of medicine. The Bible later mentions it as “spikenard”. Jatamansi is used to restore memory in older individuals as well as in patients with age-associated dementia.
Guggulu contains ferulic acids, phenols, and other non-phenolic aromatic acids that are potent scavengers of superoxide radicals. The gum resin has been used for thousands of years in the treatment of arthritis, inflammation, obesity, and disorders of cholesterol metabolism.
This is some of the western research showing the efficacy of these Ayurvedic plant medicines and the meditation.
“One of the important pathogenesis in Alzheimer's disease is the chronic inflammation of nerve cells. Several studies have demonstrated the associated inflammatory changes such as microgliosis, astrocytosis and the presence of pro-inflammatory substances that accompany the deposition of amyloid-β (Aβ) peptide. Patients with the prolonged use of certain nonsteroidal anti-inflammatory (NSAID) drugs such as ibuprofen have been shown to have a reduced risk of developing the symptoms of AD; however, the chronic use of NSAID can cause a toxic effect on the kidneys, liver and GI track. Curcumin has a potent anti-inflammatory effect. Through its various anti-inflammatory effects, it may have a role in the cure of AD”
There have been many studies done showing how ingesting this root removes Beta-Amyloid Plaques
“The most prominent characteristic feature in AD is the presence of beta-amyloid plaques. These plaques are basically an accumulation of small fibers called beta amyloid fibrils. Because the deposition of beta-amyloid protein is a consistent pathological hallmark of brains affected by AD, the inhibition of A-beta generation, prevention of A-beta fibril formation, destabilization of pre-formed A-beta would be an attractive therapeutic strategy for the treatment of AD. The levels of beta-amyloid in AD mice that were given low doses of curcumin were decreased by around 40% in comparison to those that were not treated with curcumin. In addition, low doses of curcumin also caused a 43% decrease in the so-called “plaque burden” that these beta-amyloid have on the brains of AD mice. Surprisingly low doses of curcumin given over longer period were actually more effective than high doses in combating the neurodegenerative process of AD”
This is from Forbes magazine—“ With more and more of the aging population affected by Alzheimer's disease, and clinical trials for new medications often providing underwhelming results, a new study in The American Journal of Geriatric Psychiatry may be especially promising. It finds that taking a daily dose of curcumin, the compound in turmeric root that gives curry its yellow color, may not only prevent memory problems from worsening over time, but actually improve them. And perhaps most noteworthy, these changes were seen not only in the participants' cognitive capacities, but also in their brain cells.” https://www.forbes.com/sites/alicegwalton/2018/01/23/curcumin-may-reverse-memory-problems-improve-mood/#4cf649376912
The University of California says that turmeric can provide 'meaningful cognitive benefits'
“The people who took curcumin experienced significant improvements in their memory and attention abilities, while the subjects who received placebo did not, Small said. In memory tests, the people taking curcumin improved by 28 percent over the 18 months. Those taking curcumin also had mild improvements in mood, and their brain PET scans showed significantly less amyloid and tau signals in the amygdala and hypothalamus than those who took placebos”. https://www.universityofcalifornia.edu/news/curcumin-improves-memory-and-mood-new-ucla-study-says
The plants in the formula in capsules have been well researched as well.
Withania somnifera belongs to the family Solanaceae. It (500 mg/d) exhibited calming effects on stress and reversed memory loss (Auddy et al., 2008). Cholinergic activity of Withania somnifera has been reported in a previous study (Schliebs et al., 1997). Memory enhancing activity and cognition improving property of Withania somnifera increase due to its ability to increase acetylcholine level in the brain. Neurotic outgrowth activity of Withania somnifera is reported already in human neuroblastoma cells that are time- and dose-dependent. Withania somnifera enhances dendrite and axon regeneration (Tomoharu et al., 2005). A molecular modeling study indicates that withanamides A and C bind to Aβ and inhibit fibril synthesis (Jayaprakasam et al., 2010).
Curcuma longa belongs to the family Zingiberaceae. In Southeast Asian countries, prevalence of AD is low due to consumption of turmeric. It has anti-inflammatory activity that is also associated with reduced risk of AD (Aggarwal and Harikumar, 2009). Curcumin reduces the plaque deposition in the brain. Turmeric decreases oxidative stress and amyloid pathology (Mishra and Palanivelu, 2008). In one study, administration of low doses of Curcumin reduced Aβ level up to 40% in mice with AD as compared to control drug (Shytle et al., 2009). Curcumin at low doses caused 43% decrease in the plaque burden that these Aβ have on the brain of mice with AD (Mishra and Palanivelu, 2008). A previous study indicates that low doses of Curcumin administered for long duration are more effective in the treatment of AD as compared to higher doses of Curcumin (Yang et al. 2005). Curcumin has an ability to bind with Aβ and inhibits its self assembly (Reinke and Gestwicki, 2007). Curcumin has powerful anti-inflammatory and antioxidant effects (Fan et al., 2015); according to the researchers, these effects help in treating Alzheimer's symptoms caused by inflammation and oxidation (Frautschy and Hu, 2001). Hypercholesterolemia and hyperlipidemia increase amyloid plaques by intracellular accumulation of cholesterol esters (Tokuda et al., 2000). Scientists believe that Curcumin might have therapeutic effects on AD by inhibiting cholesterol synthesis and reducing serum peroxides (Soni and Kuttan, 1992).
Convolvulus pluricaulis belongs to the family Convolvulaceae. It is used as a memory enhancing agent. A previous study has shown that aqueous and ethyl acetate extract of Convolvulus pluricaulisincreases memory functions and learning abilities (Bihaqi et al., 2011). In another study, a wide range of secondary metabolites such as steroids, anthocyanins, flavonol glycosides and triterpenoids have been isolated that are responsible for memory enhancing and nootropic properties (Malik et al., 2011). Convolvulus pluricaulishas been repoted to calm the nerves by regulating the stress hormones synthesis (cortisol and adrenaline) in the body (Sethiya et al., 2009). The ethanolic extract of Convolvulus pluricaulis and its aqueous and ethyl acetate fractions significantly improved memory retention and learning abilities in rats (Nahata et al., 2008). Another study conducted by Bihaqi et al. (2011) indicated that extracts of Convolvulus pluricaulis enhance the memory in Wistar rats in a dose-dependent manner. Similarly, administration of Convolvulus pluricaulis for 1 week increased memory in aged mice (Sharma et al., 2010). Administration of Convolvulus pluricaulis increased the acetylcholinesterase activity in the hippocampal CA1 and CA3 regions associated with the memory function and learning abilities (Dubey et al., 1994).
Centella asiatica belongs to the family Apiaceae. It contains saponins, asiaticosides, madecassoside, madasiatic acid, brahmoside, brahminoside, sasiaticoside, sitosterol, tannins, ascorbic acid, centoic acid, centellic acid, thankuniside, brahmoside, brahminoside, siatic acid, thankuniside, glycoside, triterpine, thankunic acid, vellarin, asiaticosides, thankuniside, and isothankuniside (Siddiqui et al., 2007). Centella asiatica is used in depression, rheumatism, mental weakness, abdominal pain, and epilepsy (Gohil et al., 2010). It is diuretic, anti-spasmodic, anti-convulsive, tonic, stimulant, emmenagogue, antioxidant and spermatogenic (Heidari et al., 2007). Centella asiatica reversed the Aβ pathology and reduced oxidative stress response (Amala et al., 2012).
Rao et al. (2007) reported that treatment with Centella asiatica(Linn) fresh leaf extract enhanced learning ability and memory retention power in Wistar rats. Adult rats of 2.5 months old were selected for this study. Three different doses (2, 4, and 6 mg/kg) of extracts were administered for 2, 4, and 6 weeks. Spatial learning (T-maze) and passive avoidance tests were performed after the treatment period. Results were compared with those of age matched control rats. Improvement in spatial learning was significant at the dose of 6 mL of extract. The use of Centella asiatica extract enhanced memory retention that was evident from passive avoidance test. This data showed that Centella asiatica enhances learning ability and memory retention power in adult rats. Veerendra and Gupta (2003) reported efficacy of Centella asiaticain AD. Its cognition enhancing activities and anti-oxidant effects have been reported. Aqueous extract of Centella asiatica (100, 200 and 300 mg/kg) was administered for 21 days in streptozotocin (STZ)-induced cognitive impairment and oxidative stress in rats. STZ at 3 mg/kg was intracerebroventricularly injected into male Wistar rats bilaterally on days 1 and 3. Cognitive behavior was assessed after 13, 14 and 21 days of treatment. Rats were sacrificed for assessment of oxidative stress after 21 days of treatment. Cognitive behaviors of rats treated with Centella asiatica extract improved significantly. The maximum response was observed after administration of extract at the doses of 200 and 300 mg/kg. Results from Veerendra and Gupta (2003) showed that Centella asiatica is effective in STZ-induced cognitive impairment in rats.
Celastrus paniculatus belongs to the family Celastraceae. It prevented neuronal cell damage against hydrogen peroxide toxicity due to its antioxidant activity (Godkar et al., 2006). Administration of Celastrus paniculatus prevents neuronal cell damage caused by glutamine induced toxicity (Godkar et al., 2003). Celastrus paniculatus increases cholinergic activity that contributes its ability to improving memory performance (Bhanumathy et al., 2010). Aqueous extract of Celastrus paniculatus has antioxidant and cognition enhancing properties (Kumar and Gupta, 2002). Celastrus paniculatus extracts protected neuronal cells against hydrogen peroxide induced toxicity in part by virtue of their antioxidant and free radical scavenging activities (Katekhaye et al., 2011).
Nardostachys jatamansi belongs to the family Caprifoliaceae. It contains sesquiterpene valeranone that has been used for treatment of stress (Lyle et al., 2009). In a study, Nardostachys jatamansiexhibited memory retention and learning enhancing abilities in aged and young mice and reversed scopolamine and diazepam induced amnesia. Nardostachys jatamansi also reversed aging induced amnesia (Joshi and Parle, 2006). Karkada et al. (2012) reported efficacy of Nardostachys jatamansi in the prevention of stress induced memory deficit”. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436367/
“In recent years, pharmacological and toxicological studies have begun to be published and receive attention from scientists for verification of their claimed pharmacological and therapeutic effects. The purpose of this review is to outline the molecular mechanisms, signal transduction processes, and sites of action of some Ayurvedic medicinal plants. It is hoped that this description can be further explored with modern scientific methods, to reveal new therapeutic leads and jump-start more studies on the use of Ayurvedic medicine for prevention and treatment of dementia…. Ashwagandha (Withania somnifera, fam. Solanaceae), or Indian Ginseng, is a common herb used in Ayurvedic medicine as an adaptogen or antistress agent. Ashwagandha root contains a large variety of compounds including 12 alkaloids, 40 withanolides, and several sitoindosides and flavonoids [24–26]. Withaferin A (WL-A) and withanolide A are two constituents which show similar pharmacokinetic profiles, except that the oral bioavailability for WL-A is 1.44 times greater than that of withanolide A  (Figure 2). These components produce antistress, antioxidant, and immunomodulatory effects in acute models of experimental stress [28–30]. According to Ayurvedic medicine, Ashwagandha constituents provide a number of healthful effects such as youthful state of physical and mental health and increase in happiness. It is not only given to children as tonics but is consumed by the middle-aged and elderly to increase longevity [31, 32]. Recent studies have indicated that Ashwagandha root improves the body’s defense against chronic diseases not only by improving cell-mediated immunity, but also through producing potent antioxidant and anti-inflammatory effects that protect against cellular damage caused by free radicals and inflammatory mediators [31, 32]. At the molecular level, Ashwagandha root may produce beneficial effects in AD by inhibiting the activation of NF-κB, blocking β-amyloid (Aβ) production, reducing apoptotic cell death, restoring synaptic function, and enhancing antioxidant effects through the migration of Nrf2 to the nucleus, where it increases the expression of antioxidant enzymes  (Figure 3). It is suggested that WL-A activates the translocation of Nrf2 to the nucleus, where the transcription factor upregulates the expression of neuroprotective proteins, such as heme oxygenase-1 [34, 35]. Treatment of human neuroblastoma SK-N-SH cells with methanolic extracts of Ashwagandha root results in dendrite extension, neurite outgrowth, and synapse formation [36, 37]. Moreover, treatment of cultured rat cortical neurons with Aβ (25–35) (10 M) produces axonal and dendritic atrophy and pre- and postsynaptic loss, and these changes were abrogated by treatment with WL-A (1 M) . WL-A also attenuates the expression of semaphorin 3A to facilitate neural regeneration. The beneficial effects of Ashwagandha root constituents in neurodegenerative diseases may be due to their neurite promoting, antioxidant, anti-inflammatory, antiapoptotic, and anxiolytic activities, as well as their ability to improve mitochondrial dysfunction and restore energy levels and increase levels of antioxidant defenses such as reduced glutathione” https://www.hindawi.com/journals/ecam/2018/2481076/
“ It is estimated that within the next 50 years approximately 30% of the population will be aged 65 years or older, and six million of those between 75 and 84 years of age, will exhibit some form of Alzheimer’s disease (AD) symptoms (Bradford & Gupta, 2005Bradford B, Gupta S. (2005). A review of antioxidants and Alzheimer’s disease. Ann Clin Psychiatry, 17, 269–286. [Google Scholar]).
According to Ayurveda, the traditional Indian System of Medicine, AD is an imbalance of vata, pitta and kapha. Medhya Rasyanas (drugs which act as nervine tonic) such as shankhpushpi, Brhami [Bacopa moniera Wettst. (Scrophulariaceae)], Vacha [Acorus calamus Linn. (Acoraceae)] and Jyotishmati [Celastrus paniculatus Willd. (Celastraceae)] are beneficial in cognitive disorders (Joshi & Parle, 2006Joshi H, Parle M. (2006). Brahmi rasayanaimproves learning and memory in mice. Evid Based Complement Alternat Med, 3, 79–85.[Crossref], [PubMed], [Web of Science ®], , [Google Scholar]). ‘Charak Samhita’ has described shankhpushpi as one of the best Medhya rasayana or brain tonic” https://www.tandfonline.com/doi/full/10.3109/13880209.2011.584539
From the Journal of Alzheimer’s Disease is this report of using Kirtan Kriya, a part of this Ayurvedic treatment, for this disease.
“Results: Fourteen yoga and 11 MET participants completed the study. The yoga group demonstrated a statistically significant improvement in depression and visuospatial memory. We observed improved verbal memory performance correlated with increased connectivity between the DMN and frontal medial cortex, pregenual anterior cingulate cortex, right middle frontal cortex, posterior cingulate cortex, and left lateral occipital cortex. Improved verbal memory performance positively correlated with increased connectivity between the language processing network and the left inferior frontal gyrus. Improved visuospatial memory performance correlated inversely with connectivity between the superior parietal network and the medial parietal cortex.
Conclusion:Yoga may be as effective as MET in improving functional connectivity in relation to verbal memory performance. These findings should be confirmed in larger prospective studies”. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927889/
This is a quote from a British nursing home where this meditation is practiced. “Meditation: 'The effects of Kirtan Kriya are instant - all care homes should do it' https://www.carehome.co.uk/news/article.cfm/id/1599748/Meditation-The-effects-of-Kirtan-Kriya-are-instant-all-care-homes-should-do-it
From “Alzheimer’s Universe” we read this--
“Benefits of Kirtan Kriya
Recent studies have shown several benefits of regular Kirtan Kriya practice, including:
Improvement in blood flow to the brain (including specific areas involved in memory retrieval)
Increase in brain wave activity in the frontal lobe resulting in the sharpening of attention, concentration, and focus
Increase in brain chemicals and important neurotransmitters such as acetylcholine, dopamine and norepinephrine (all which help the brain function better)
Increase in energy levels and improvement in the quality of sleep
Reduction in cortisol levels (the stress hormone)
Improvement of mood, psychological health and spiritual well-being” https://www.alzu.org/blog/2017/08/30/the-alzheimers-research-prevention-foundations-brain-longevity-therapy-training-program/
This article originally appeared in Mind, Mood & Memory, a publication of the Department of Psychiatry at Massachusetts General Hospital dedicated to maintaining mental fitness from middle age and beyond.
The National Institute for the Clinical Application of Behavioral Medicine did their own small study on improving memory with Kirtan Kriya.
Even WebMD, that conservation bastion of allopathic medicine, has acknowledged the benefits of Kirtan Kriya to reverse memory loss. “Mar 3, 2010 -- Meditation can increase blood flow in the brain and improve memory, according to researchers who tested a specific kind of meditation and found the improvement after just eight weeks.
The 15 participants, ages 52 to 77, all had memory problems at the start, says Dharma Singh Khalsa, MD, one of the researchers and the medical director of the Alzheimer's Research and Prevention Foundation in Tucson, Ariz….”https://www.webmd.com/alzheimers/news/20100303/can-meditation-reverse-memory-loss#1
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